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Aging

Highlights

Thanks to animal research, researchers are studying potential drugs to boost immune functions and slow the aging process.
The diabetes drug Metformin has been found to stall the aging process in mice.
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Common chronic illnesses like neurodegeneration, cancer, and heart disease have come into focus as processes linked by aging. Points along these pathways have offered promising new drug targets.

Pitt's Contributions

Toren Finkel, director of Pitt’s Aging Institute, has shown that in the area of a mouse’s brain that encodes learning and memory, a critical recycling process within cells slows dramatically with age.

永久免费梯子加速器 Years U.S. life expectancy in 1918
78.8 Years today
46 Million Americans age 65 or older
>90^% Elderly people have a chronic health problem

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Nonhuman primates are essential to our knowledge of the human brain.
Researchers have used mouse models to help determine the disease’s genetic factors and to pioneer immunotherapy treatments as well as a possible drug-free treatment.

Pitt's Contributions

In 2004, Pitt’s William Klunk and Chester Mathis completed the first human study of Pittsburgh Compound B. This PET-scan dye, which was first tested in animals, proved an effective way to make the hallmarks of Alzheimer’s visible in living people for the first time.

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500000 New diagnoses expected in 2018

Brain-Machine Interface

Highlights

In the 1960s, for the first time, neuroscientists implant an electrode to monitor the activities of a brain cell in an active monkey.
Four decades later, Pitt Professor Andrew Schwartz and his team train Rhesus monkeys to conduct certain tasks using only their brains.
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Two years later, research by Pitt's Robert Gaunt and Jennifer Collinger leads to a man with quadriplegia controlling a robotic arm—and even feeling sensation—via tiny brain implants.
In 2019, researchers at Pitt and Carnegie Mellon University discovered how the brain changes when mastering a new skill.

Cancer

Highlights

Through research with dogs, rodents and other species, scientists have developed sophisticated and effective cancer treatments, including gene therapy and immunotherapy.
Chemotherapy was developed by using modified mustard gas to reduce tumors in mice.
Immunotherapy, one of cancer therapy’s greatest advances in a generation, began with the discovery that blocking a molecule called PD1 could coax the immune systems of mice to kill tumors.

Pitt's Contributions

Pitt’s Greg Delgoffe is learning what separates those who respond to PD1-targeted therapy from those who do. In the former, helpful immune cells are “starving,” while not-so-helpful ones beef up.

Mental Health

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Animal testing has played a crucial role in the development of anti-psychotic drugs.
For example, the widely prescribed anti-psychotic drug Abilify was tested on rats, dogs, monkeys and rabbits to ensure its safety and efficacy.
Research into mental illness also benefits pets. Dogs and cats can suffer from anxiety and depression.

7 Million Americans living with bipolar disorder or schizophrenia
20^% of U.S. adults have a mental health condition

Organ Transplants

Highlights

Research with rabbits leads, in 1905, to the first successful human transplant — a cornea implant.
Dogs, rabbits and mice have been key to the development of surgical techniques and anti-rejection drugs.
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The pioneering work of Thomas Starzl and others established Pitt as a world leader in organ transplantation.

Parkinson's Disease

Highlights

Animal models were essential for current treatments.
Deep brain stimulation (DBS) in monkeys with Parkinson’s led to DBS treatment for humans as well, helping patients manage their symptoms.
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Polio

Highlights

In 1954, Jonas Salk and his Pitt team create the first effective vaccine. This follows four decades of research by Salk’s team and others, conducted with mice, rats and monkeys.
Albert Sabin’s team creates an oral vaccine in 1960 through research with rabbits, monkeys and rodents.

57900 New U.S. cases in 1954
99^% Eradicated worldwide today

Tuberculosis

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• In 2020, researchers at Pitt’s School of Medicine and the National Institute of Allergy and Infectious Diseases discovered that intravenous TB vaccination is highly protective against the infection in monkeys, compared to the standard injection directly into the skin, which offers minimal protection.

Nobel Prize-winning research on guinea pigs led to the first antibiotic effective against tuberculosis. (Even with vaccination, TB continues to kill more people than any other infectious disease.)

• In addition, artificially infected mice, rabbits and monkeys have been indispensable in studying transmission, vaccines, genetic resistance and other facets of TB.

• TB tests developed in 2019 are expected to lead to vaccination programs for cows.

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